Bull Vet Inst Pulawy 55, 741-748, 2011

full text

MULTI-CLASS PROCEDURE FOR ANALYSIS OF ANTIBACTERIAL COMPOUNDS IN ANIMAL TISSUES BY LIQUID CHROMATOGRAPHYTANDEM MASS SPECTROMETRY

TOMASZ BŁĄDEK, ANDRZEJ POSYNIAK, ANNA GAJDA, MAŁGORZATA GBYLIK, AND JAN ŻMUDZKI

A liquid chromatographic method coupled with tandem mass spectrometry for the determination of residues of β-lactams, macrolides, tetracyclines, quinolones, sulfonamides, aminoglycosides, and lincosamides in animal tissues was described. Analytes were isolated from biological material with acetonitrile or with trichloroacetic acid. The procedure was validated according to European Decision 2002/657/EC

Key words: animal tissues, antibiotics, HPLC–MS/MS.